This one's for the drug Verapamil
The doc gives it out when you're feelin' ill
When you feel that your heart be actin' up

It'll find ion channels and plug 'em up

The ion, Ca2+, wants to flow in the cell

To depolarize the heart when all is well
But Verapamil acts as a channel blocker
Just beats out the Ca2+ like a big fat bouncer


Your heart's goin' fast, fast; it's never gonna last, last
So you took the drug, drug, took it with a shrug, shrug

Then your heart started slowin' down
Doc said that's right, you're on the rebound


I said, that's cool but what about a nerve?
I mean, how would it work, would the pathway preserve?
No Ca2+ channels so what's up with that

Is it cool if I stick my nerve in a Verapamil bath?

No its not, no its not

It's gonna block the potassium channel like a dried snot
Now the cell can't really repolarize
So the action potential's gonna grow lengthwise


BOY YOU GOT MY HEARTBEAT RUNNIN' AWAY
BEATING LIKE A DRUM AND ITS RUNNIN' ASTRAY

CAN'T YOU HEAR THAT BOOM BADOOM BOOM
BOOM BADOOM BOOM BASS?


(Its arrhythmia)
BOOM BADOOM BOOM
BOOM BADOOM BOOM BASS

ITS ARRHYTHMIA

Boom, badoom, boom

Boom, badoom, boom, he's got arrythmia
Boom, badoom, boom
Boom, badoom, boom, he's got arrythmia


This one is for the drug Amiodarone
This one won't stop at potassium alone

It can block K+ channels, it can block Na2+
Be it heart or nerve, it works the same way


Like Verapamil this drug is used for arrhythmia
Depolarization slows like in a coma
Repolarization ain't gonna work, and when it don't work

The AP won't take off, off, uh

Excuse me, this is really awesome

But what about high extracellular calcium
I mean, sigh, I really like milk
If I put my nerve in it will I start to feel ill?


Yes you are, yes you are
Those calcium ions are way too large

They're gonna block up, they're gonna get stuck
in the sodium channels and wreak havoc!


Now you know what all these drug treatments do
Prolonging those CAPs in nervous tissue
We can't hear that boom, badoom, boom

boom, badoom boom bass

Our hearts won't race

Cause now, now we know what to take, take
Yeah what to take